Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Jun;49(6):929-931.
doi: 10.1111/cea.13389. Epub 2019 Apr 9.

Do eosinophils contribute to oxidative stress in mild asthma?

Affiliations
Review

Do eosinophils contribute to oxidative stress in mild asthma?

Linsey E S de Groot et al. Clin Exp Allergy. 2019 Jun.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interests.

Figures

Figure 1
Figure 1
Exhaled breath condensate (EBC) levels of MDA (A, D, G and J), nitrotyrosine (B, E, H and K) and asymmetric dimethylarginine (ADMA) (C, F, I and L) before and after RV16 challenge and corresponding delta values in patients treated with placebo (black dots) or mepolizumab (grey triangles). Dots/triangles represent patient individuals; bars and whiskers represent mean ± SEM. Paired or unpaired t‐tests: *< 0.05

References

    1. Nadeem A, Chhabra SK, Masood A, Raj HG. Increased oxidative stress and altered levels of antioxidants in asthma. J Allergy Clin Immunol. 2003;111(1):72‐78. - PubMed
    1. Kimpen JL, Garofalo R, Welliver RC, Ogra PL. Activation of human eosinophils in vitro by respiratory syncytial virus. Pediatr Res. 1992;32(2):160‐164. - PubMed
    1. Lavinskiene S, Malakauskas K, Jeroch J, Hoppenot D, Sakalauskas R. Functional activity of peripheral blood eosinophils in allergen‐induced late‐phase airway inflammation in asthma patients. J Inflamm (Lond). 2015;12:25. - PMC - PubMed
    1. Wu W, Samoszuk MK, Comhair SA, et al. Eosinophils generate brominating oxidants in allergen‐induced asthma. J Clin Investig. 2000;105(10):1455‐1463. - PMC - PubMed
    1. MacPherson JC, Comhair SA, Erzurum SC, et al. Eosinophils are a major source of nitric oxide‐derived oxidants in severe asthma: characterization of pathways available to eosinophils for generating reactive nitrogen species. J Immunol. 2001;166(9):5763‐5772. - PubMed