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. 2019 Mar 14:74:e739.
doi: 10.6061/clinics/2019/e739.

Is there any association between osteoporotic vertebral fracture and vitamin K epoxide reductase complex subunit-1 polymorphism in Turkish society? A pilot study

Merih Ozgen  1 , Didem Turgut Cosan  2 , Fulya Doganer  3 , Ahu Soyocak  4 , Onur Armagan  1 , Selen Kuzgun  5 , Ayse Merve Aydogan  1 , Hasan Veysi Gunes  2 , Irfan Degirmenci  6 , Fezan Mutlu  7
Affiliations

Is there any association between osteoporotic vertebral fracture and vitamin K epoxide reductase complex subunit-1 polymorphism in Turkish society? A pilot study

Merih Ozgen et al. Clinics (Sao Paulo). .

Abstract

Objective: In this study, the relationship between osteoporotic vertebral fractures and 9041 Guanine/Adenine and 3673 Guanine/Adenine polymorphisms related to the vitamin K epoxide reductase complex subunit-1 (VKORC1) gene in postmenopausal women with osteoporosis was investigated.

Method: DNA was isolated from blood samples collected from 150 women with postmenopausal osteoporosis. Genotyping of the two polymorphic regions (9041 Guanine/Adenine and 3673 Guanine/Adenine) in VKORC1 was performed using polymerase chain reaction-restriction fragment length polymorphism analysis. The presence of radiographic fractures among the 150 patients was ascertained by using the Genant method.

Result: At least one fracture was detected in 98 patients, and no fracture was observed in 52 patients on radiological images. We found no association between the 9041 Guanine/Adenine (p=0.283) and 3673 Guanine/Adenine (p=0.232) polymorphisms of the VKORC1 gene and the development of secondary postosteoporotic fractures in our study.

Conclusion: There was no relationship between osteoporotic vertebral fracture and VKORC1 gene polymorphism in a postmenopausal Turkish population.

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Conflict of interest statement

No potential conflict of interest was reported.

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