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. 2019 Mar 14;53(2):206-212.
doi: 10.2478/raon-2019-0016.

The influence of genetic variability of DNA repair mechanisms on the risk of malignant mesothelioma

Kristina Levpuscek  1 , Katja Goricar  2 , Viljem Kovac  3 , Vita Dolzan  2 , Alenka Franko  4
Affiliations

The influence of genetic variability of DNA repair mechanisms on the risk of malignant mesothelioma

Kristina Levpuscek et al. Radiol Oncol. .

Abstract

Background Malignant mesothelioma (MM) is a rare aggressive tumour of mesothelium caused by asbestos exposure. It has been suggested that the genetic variability of proteins involved in DNA repair mechanisms affects the risk of MM. This study investigated the influence of functional polymorphisms in ERCC1 and XRCC1 genes, the interactions between these polymorphisms as well as the interactions between these polymorphisms and asbestos exposure on MM risk. Patients and methods In total, 237 cases with MM and 193 controls with no asbestos-related disease were genotyped for ERCC1 and XRCC1 polymorphisms. Results ERCC1 rs3212986 polymorphism was significantly associated with a decreased risk of MM (odds ratio [OR] = 0.61; 95% confidence interval [CI] = 0.41-0.91; p = 0.014). No associations were observed between other genetic polymorphisms and MM risk. Interactions between polymorphisms did not significantly influence MM risk. Interaction between ERCC1 rs11615 and asbestos exposure significantly influenced MM risk (OR = 3.61; 95% CI = 1.12-11.66; p = 0.032). Carriers of polymorphic ERCC1 rs11615 allele who were exposed to low level of asbestos had a decreased risk of MM (OR = 0.40; 95% CI = 0.19-0.84; p = 0.016). Interactions between other polymorphisms and asbestos exposure did not significantly influence MM risk. Conclusions Our findings suggest that the genetic variability of DNA repair mechanisms could contribute to the risk of developing MM.

Keywords: DNA repair mechanisms; ERCC1; XRCC1; genetic polymorphism; malignant mesothelioma.

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References

    1. Carbone M, Ly BH, Dodson RF, Pagano I, Morris PT, Dogan UA. Malignant mesothelioma: facts, myths, and hypotheses. J Cell Physiol. 2012;227:44. doi: 10.1002/jcp.22724. et al. –. - DOI - PMC - PubMed
    1. Linton A, Vardy J, Clarke S. van Zandwijk N. The ticking time-bomb of asbestos: its insidious role in the development of malignant mesothelioma. Crit Rev Oncol Hematol. 2012;84:200. doi: 10.1016/j.critrevonc.2012.03.001. –. - DOI - PubMed
    1. Franko A, Kotnik N, Goricar K, Kovac V, Dodic-Fikfak M, Dolzan V. The influence of genetic variability on the risk of developing malignant mesothelioma. Radiol Oncol. 2018;52:105. doi: 10.2478/raon-2018-0004. –. - DOI - PMC - PubMed
    1. Remon J, Lianes P, Martinez S, Velasco M, Querol R, Zanui M. Malignant mesothelioma: new insights into a rare disease. Cancer Treat Rev. 2013;39:584. doi: 10.1016/j.ctrv.2012.12.005. –. - DOI - PubMed
    1. Franko A, Dolzan V, Kovac V, Arneric N, Dodic-Fikfak M. Soluble mesothelinrelated peptides levels in patients with malignant mesothelioma. Dis Markers. 2012;32:123. doi: 10.3233/DMA-2011-0866. –. - DOI - PMC - PubMed

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