Sugar Fix Keeps RIPK3 at Bay
- PMID: 30893581
- DOI: 10.1016/j.immuni.2019.02.018
Sugar Fix Keeps RIPK3 at Bay
Abstract
Immunometabolism is emerging as an important modulator of immune responses. In this issue of Immunity, Li et al. (2019) examine the link between lipopolysaccharide (LPS)-induced glucose metabolism and innate immune signaling and identify how β-N-acetylglucosamine (O-GlcNAc) modification of the RIPK3 RHIM domain limits inflammation and necroptosis.
Copyright © 2019 Elsevier Inc. All rights reserved.
Comment on
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O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3.Immunity. 2019 Mar 19;50(3):576-590.e6. doi: 10.1016/j.immuni.2019.01.007. Epub 2019 Feb 12. Immunity. 2019. PMID: 30770249 Free PMC article.
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