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Comment
. 2019 Mar 19;50(3):539-541.
doi: 10.1016/j.immuni.2019.02.018.

Sugar Fix Keeps RIPK3 at Bay

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Sugar Fix Keeps RIPK3 at Bay

Cristina Giogha et al. Immunity. .
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Abstract

Immunometabolism is emerging as an important modulator of immune responses. In this issue of Immunity, Li et al. (2019) examine the link between lipopolysaccharide (LPS)-induced glucose metabolism and innate immune signaling and identify how β-N-acetylglucosamine (O-GlcNAc) modification of the RIPK3 RHIM domain limits inflammation and necroptosis.

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