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Comment
. 2019 Mar 19;50(3):544-546.
doi: 10.1016/j.immuni.2019.02.017.

Visualizing the Heterogeneity of Retinal Microglia

Jonathan B Lin  1 , Rajendra S Apte  2
Affiliations
Comment

Visualizing the Heterogeneity of Retinal Microglia

Jonathan B Lin et al. Immunity. .

Abstract

In this issue of Immunity, O'Koren et al. (2019) report that murine retinal microglia are long lived and are divided into two spatially and functionally distinct niches in the retina. In models of retinal neurodegeneration, retinal microglia migrate to the subretinal space, an inducible disease-associated niche, where they are neuroprotective.

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Figures

Figure 1.
Figure 1.. Microglia Serve Important Functions at Baseline and in Disease.
Under homeostatic conditions (left), microglia in the murine retina are located in spatially and functionally distinct niches in the outer plexifom layer (OPL) and the inner plexiform layer (IPL). In retinal neurodegenerative disease (right), both populations of microglia migrate to the subretinal space, where they play a neuroprotective role.
See this image and copyright information in PMC

Comment on

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