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Comment
. 2019 Mar 19;50(3):549-551.
doi: 10.1016/j.immuni.2019.02.020.

Recasting the Tissue-Resident Lymphocyte in Celiac Disease

Hisako Kayama  1 , Kiyoshi Takeda  2
Affiliations
Free article
Comment

Recasting the Tissue-Resident Lymphocyte in Celiac Disease

Hisako Kayama et al. Immunity. .
Free article

Abstract

In a recent issue of Cell, Mayassi et al. (2019) show that chronic inflammation in celiac disease (CeD) patients changes the repertoire and functional phenotype of intestinal TCR γδ+ intraepithelial lymphocytes. These changes are not reversed by gluten-free dietary regimens, suggesting that they might underlie the long-term sensitivity of CeD patients to gluten.

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  • Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease.
    Mayassi T, Ladell K, Gudjonson H, McLaren JE, Shaw DG, Tran MT, Rokicka JJ, Lawrence I, Grenier JC, van Unen V, Ciszewski C, Dimaano M, Sayegh HE, Kumar V, Wijmenga C, Green PHR, Gokhale R, Jericho H, Semrad CE, Guandalini S, Dinner AR, Kupfer SS, Reid HH, Barreiro LB, Rossjohn J, Price DA, Jabri B. Mayassi T, et al. Cell. 2019 Feb 21;176(5):967-981.e19. doi: 10.1016/j.cell.2018.12.039. Epub 2019 Feb 7. Cell. 2019. PMID: 30739797 Free PMC article.