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Review
. 2019 Mar 19;11(3):273.
doi: 10.3390/v11030273.

Meal for Two: Human Cytomegalovirus-Induced Activation of Cellular Metabolism

Irene Rodríguez-Sánchez  1 , Joshua Munger  2   3
Affiliations
Review

Meal for Two: Human Cytomegalovirus-Induced Activation of Cellular Metabolism

Irene Rodríguez-Sánchez et al. Viruses. .

Abstract

Viruses are parasites that depend on the host cell's metabolic resources to provide the energy and molecular building blocks necessary for the production of viral progeny. It has become increasingly clear that viruses extensively modulate the cellular metabolic network to support productive infection. Here, we review the numerous ways through which human cytomegalovirus (HCMV) modulates cellular metabolism, highlighting known mechanisms of HCMV-mediated metabolic manipulation and identifying key outstanding questions that remain to be addressed.

Keywords: HCMV; amino acid; fatty acids; glutaminolysis; glycolysis; host–virus interactions; human cytomegalovirus; mTOR; metabolism; pyrimidine.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Central Carbon Metabolism.
Figure 2
Figure 2
Pyrimidine and Nucleotide Sugar Metabolism.
Figure 3
Figure 3
Fatty Acid Biosynthesis, Elongation and Desaturation.
Figure 4
Figure 4
Prostaglandin Biosynthesis.
See this image and copyright information in PMC

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