Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Mar 19;20(6):1371.
doi: 10.3390/ijms20061371.

Peroxiporins in Cancer

Cecilia Prata  1 , Silvana Hrelia  2 , Diana Fiorentini  3
Affiliations
Review

Peroxiporins in Cancer

Cecilia Prata et al. Int J Mol Sci. .

Abstract

The transport of H₂O₂ across membranes by specific aquaporins (AQPs) has been considered the last milestone in the timeline of hydrogen peroxide discoveries in biochemistry. According to its concentration and localization, H₂O₂ can be dangerous or acts as a signaling molecule in various cellular processes as either a paracrine (intercellular) and/or an autocrine (intracellular) signal. In this review, we investigate and critically examine the available information on AQP isoforms able to facilitate H₂O₂ across biological membranes ("peroxiporins"), focusing in particular on their role in cancer. Moreover, the ability of natural compounds to modulate expression and/or activity of peroxiporins is schematically reported and discussed.

Keywords: aquaporins; cancer; hydrogen peroxide; peroxiporins; phytochemicals; redox signaling.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Agre P., Sasaki S., Chrispeels M.J. Aquaporins: A family of water channel proteins. Am. J. Physiol. 1993;265:F461. doi: 10.1152/ajprenal.1993.265.3.F461. - DOI - PubMed
    1. Agre P. Nobel Lecture. Aquaporin water channels. Biosci. Rep. 2004;24:127–163. doi: 10.1007/s10540-005-2577-2. - DOI - PubMed
    1. King L.S., Kozono D., Agre P. From structure to disease: The evolving tale of aquaporin biology. Nat. Rev. Mol. Cell Biol. 2004;5:687–698. doi: 10.1038/nrm1469. - DOI - PubMed
    1. Laforenza U., Pellavio G., Marchetti A.L., Omes C., Todaro F., Gastaldi G. Aquaporin-Mediated Water and Hydrogen Peroxide Transport Is Involved in Normal Human Spermatozoa Functioning. Int. J. Mol. Sci. 2016;18:66. doi: 10.3390/ijms18010066. - DOI - PMC - PubMed
    1. Jahn T.P., Moller A.L., Zeuthen T., Holm L.M., Klaerke D.A., Mohsin B., Kuhlbrandt W., Schjoerring J.K. Aquaporin homologues in plants and mammals transport ammonia. FEBS Lett. 2004;574:31–36. doi: 10.1016/j.febslet.2004.08.004. - DOI - PubMed

LinkOut - more resources