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Comment
. 2019 Jun;15(6):1115-1116.
doi: 10.1080/15548627.2019.1596498. Epub 2019 Mar 27.

Adventures in spacetime: circadian rhythms and the dynamics of protein catabolism

Mikhail Ryzhikov  1 , Anna Ehlers  1 , Jeffrey A Haspel  1
Affiliations
Comment

Adventures in spacetime: circadian rhythms and the dynamics of protein catabolism

Mikhail Ryzhikov et al. Autophagy. 2019 Jun.

Abstract

Circadian rhythms help cells to organize complex processes, but how they shape the kinetics of protein catabolism is unclear. In a recent paper, we employed proteomics to map daily biological rhythms in autophagic flux in mouse liver, and correlated these rhythms with proteasome activity. We also explored the effect of inflammation caused by endotoxin on autophagy dynamics. Our data provide insight into how circadian rhythms serve as a framework for connecting the spatial, temporal, and metabolic aspects of autophagy at a system-wide level. Our observations also have implications for how to optimize autophagy-directed therapies in patients.

Keywords: Autophagy; circadian rhythms; endotoxin; inflammation; macroautophagy; proteasome; proteomics.

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Figures

Figure 1.
Figure 1.
Autophagy is regulated around a 24-h rhythm in mouse liver, catabolizing substrates during the day or night-time in distinct cellular regions.
See this image and copyright information in PMC

Comment on

  • Diurnal Rhythms Spatially and Temporally Organize Autophagy.
    Ryzhikov M, Ehlers A, Steinberg D, Xie W, Oberlander E, Brown S, Gilmore PE, Townsend RR, Lane WS, Dolinay T, Nakahira K, Choi AMK, Haspel JA. Ryzhikov M, et al. Cell Rep. 2019 Feb 12;26(7):1880-1892.e6. doi: 10.1016/j.celrep.2019.01.072. Cell Rep. 2019. PMID: 30759397 Free PMC article.

References

    1. Ryzhikov M, Ehlers A, Steinberg A, et al. Dirunal rhythms spatially and temporally organize autophagy. Cell Rep. 2019;26:1880–1892. - PMC - PubMed

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