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. 2019 Mar 20;17(1):95.
doi: 10.1186/s12967-019-1842-2.

Overexpression of scavenger receptor and infiltration of macrophage in epicardial adipose tissue of patients with ischemic heart disease and diabetes

Concepción Santiago-Fernández  1   2 , Luis M Pérez-Belmonte  3   4 , Mercedes Millán-Gómez  5   6 , Inmaculada Moreno-Santos  5   6 , Fernando Carrasco-Chinchilla  5   6 , Amalio Ruiz-Salas  5   6 , Luis Morcillo-Hidalgo  5   6 , José M Melero  5   6 , Lourdes Garrido-Sánchez  7   8 , Manuel Jiménez-Navarro  5   6
Affiliations

Overexpression of scavenger receptor and infiltration of macrophage in epicardial adipose tissue of patients with ischemic heart disease and diabetes

Concepción Santiago-Fernández et al. J Transl Med. .

Abstract

Background: Oxidized low-density lipoproteins and scavenger receptors (SRs) play an important role in the formation and development of atherosclerotic plaques. However, little is known about their presence in epicardial adipose tissue (EAT). The objective of the study was to evaluate the mRNA expression of different SRs in EAT of patients with ischemic heart disease (IHD), stratifying by diabetes status and its association with clinical and biochemical variables.

Methods: We analyzed the mRNA expression of SRs (LOX-1, MSR1, CXCL16, CD36 and CL-P1) and macrophage markers (CD68, CD11c and CD206) in EAT from 45 patients with IHD (23 with type 2 diabetes mellitus (T2DM) and 22 without T2DM) and 23 controls without IHD or T2DM.

Results: LOX-1, CL-P1, CD68 and CD11c mRNA expression were significantly higher in diabetic patients with IHD when compared with those without T2DM and control patients. MSR1, CXCL16, CD36 and CD206 showed no significant differences. In IHD patients, LOX-1 (OR 2.9; 95% CI 1.6-6.7; P = 0.019) and CD68 mRNA expression (OR 1.7; 95% CI 0.98-4.5; P = 0.049) were identified as independent risk factors associated with T2DM. Glucose and glycated hemoglobin were also shown to be risk factors.

Conclusions: SRs mRNA expression is found in EAT. LOX-1 and CD68 and were higher in IHD patients with T2DM and were identified as a cardiovascular risk factor of T2DM. This study suggests the importance of EAT in coronary atherosclerosis among patients with T2DM.

Keywords: Diabetes mellitus; Epicardial adipose tissue; Ischemic heart disease; Oxidized low-density lipoprotein; Scavenger receptors.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Levels of mRNA expression of SRs, macrophage infiltration and LRP1 in human epicardial adipose tissue in the three groups of patients. a Levels of mRNA expression of LOX-1. b Levels of mRNA expression of CL-P1. c Levels of mRNA expression of MSR1. d Levels of mRNA expression of CXCL16. e Levels of mRNA expression of CD68. f Levels of mRNA expression of CD36. g Levels of mRNA expression of CD11c. h Levels of mRNA expression of CD206. i Levels of mRNA expression of LRP1
Fig. 2
Fig. 2
Ratio of CD11c/CD68 and CD206/CD68 in human epicardial adipose tissue in the three groups of patients. a Ratio of CD11c/CD68. b Ratio of CD206/CD68
See this image and copyright information in PMC

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