Comment on

• DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation.

  Winter GE, Buckley DL, Paulk J, Roberts JM, Souza A, Dhe-Paganon S, Bradner JE. Winter GE, et al. Science. 2015 Jun 19;348(6241):1376-81. doi: 10.1126/science.aab1433. Epub 2015 May 21. Science. 2015. PMID: 25999370 Free PMC article.
• Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4.

  Zengerle M, Chan KH, Ciulli A. Zengerle M, et al. ACS Chem Biol. 2015 Aug 21;10(8):1770-7. doi: 10.1021/acschembio.5b00216. Epub 2015 Jun 16. ACS Chem Biol. 2015. PMID: 26035625 Free PMC article.
• Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4.

  Lu J, Qian Y, Altieri M, Dong H, Wang J, Raina K, Hines J, Winkler JD, Crew AP, Coleman K, Crews CM. Lu J, et al. Chem Biol. 2015 Jun 18;22(6):755-63. doi: 10.1016/j.chembiol.2015.05.009. Epub 2015 Jun 4. Chem Biol. 2015. PMID: 26051217 Free PMC article.
• HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins.

  Buckley DL, Raina K, Darricarrere N, Hines J, Gustafson JL, Smith IE, Miah AH, Harling JD, Crews CM. Buckley DL, et al. ACS Chem Biol. 2015 Aug 21;10(8):1831-7. doi: 10.1021/acschembio.5b00442. Epub 2015 Jun 23. ACS Chem Biol. 2015. PMID: 26070106 Free PMC article.
• Catalytic in vivo protein knockdown by small-molecule PROTACs.

  Bondeson DP, Mares A, Smith IE, Ko E, Campos S, Miah AH, Mulholland KE, Routly N, Buckley DL, Gustafson JL, Zinn N, Grandi P, Shimamura S, Bergamini G, Faelth-Savitski M, Bantscheff M, Cox C, Gordon DA, Willard RR, Flanagan JJ, Casillas LN, Votta BJ, den Besten W, Famm K, Kruidenier L, Carter PS, Harling JD, Churcher I, Crews CM. Bondeson DP, et al. Nat Chem Biol. 2015 Aug;11(8):611-7. doi: 10.1038/nchembio.1858. Epub 2015 Jun 10. Nat Chem Biol. 2015. PMID: 26075522 Free PMC article.