Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Feb 27;7(4):690-695.
doi: 10.3889/oamjms.2019.151. eCollection 2019 Feb 28.

Prognostic Factors of Local-Regional Recurrence in Patients with Operable Breast Cancer in Asia: A Meta-Analysis

Wirsma Arif Harahap  1 , Ricvan Dana Nindrea  2   3
Affiliations
Review

Prognostic Factors of Local-Regional Recurrence in Patients with Operable Breast Cancer in Asia: A Meta-Analysis

Wirsma Arif Harahap et al. Open Access Maced J Med Sci. .

Abstract

Background: Cause of recurrence of breast cancer is multifactorial. Also, the occurrence of breast cancer in Asian patients has some different factors from the recurrence of breast cancer in western countries.

Aim: This study aims to determine the prognostic factors of local-regional recurrence in patients with operable breast cancer in Asia.

Methods: The authors conducted a meta-analysis of published research articles published in an online database of PubMed, ProQuest and EBSCO between January 2000 and July 2018. Pooled risk ratios (RR) were calculated using fixed and random-effect models. Data were processed by using Review Manager 5.3 (RevMan 5.3).

Results: This study reviewed 879 articles. There were 11 studies conducted a systematic review then continued by meta-analysis of relevant data with total patients involved were 5,213 patients. The prognostic factors found of local-regional recurrence in patients with operable breast cancer were Nodal (N) stage with the highest risk ratio (RR = 6.35 [95% CI 3.78-10.67]) followed by HER2 positive (RR = 2.14 [95% CI 1.16-3.97]), stage of cancer (RR = 1.82 [95% CI 1.44-2.31]), tumor size (RR = 1.55 [95% CI 1.04-2.31]), tumor grade (RR = 1.43 [95% CI 1.23-1.65]), PR status (RR = 0.65 [95% CI 0.48-0.88]) and the least was ER status (RR = 0.60 [95% CI 0.39-0.91]). Homogeneity of variance was found in N stage, tumor size and tumor grade for recurrence of operable breast cancer.

Conclusion: This meta-analysis confirmed the correlation of N stage, HER2, stage of cancer, tumour size, tumour grade, ER and PR status with recurrence in patients with operable breast cancer in Asia.

Keywords: Asian Population; Operable breast cancer; Prognostic factors; Recurrence.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Flow diagram research procedure
Figure 2
Figure 2
Forest plots prognostic factors of local-regional recurrence in patients with operable breast cancer in Asia
Figure 3
Figure 3
Funnel plots prognostic factors of local-regional recurrence in patients with operable breast cancer in Asia
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Nindrea RD, Aryandono T, Lazuardi L. Breast cancer risk from modifiable and non-modifiable risk factors among women in Southeast Asia:a meta-analysis. Asian Pac J Cancer Prev. 2017;18:3201–6. PMid:29281867 PMCid:PMC5980871. - PMC - PubMed
    1. Nindrea RD, Harahap WA, Aryandono T, Lazuardi L. Association of BRCA1 Promoter methylation with breast cancer in Asia:a meta- analysis. Asian Pac J Cancer Prev. 2018;19:885–9. PMid:29693332. - PMC - PubMed
    1. Sestak I, Dowsett M, Zabaglo L, Lopez-Knowles E, Ferree S, Cowens JW, et al. Factors predicting late recurrence for estrogen receptor-positive breast cancer. J Natl Cancer Inst. 2013;105:1504–11. https://doi.org/10.1093/jnci/djt244 PMid:24029245. - PMC - PubMed
    1. Nishimura R, Osako T, Nishiyama Y, Tashima R, Nakano M, Fujisue M, et al. Evaluation of factors related to late recurrence—later than 10 years after the initial treatment—in primary breast cancer. Oncology. 2013;85:100–10. https://doi.org/10.1159/000353099 PMid:23867253. - PubMed
    1. Davies C, Godwin J, Gray R, Clarke M, Cutter D, et al. Early Breast Cancer Trialists Collaborative Group. Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen:patient-level meta-analysis of randomised trials. Lancet. 2011;378:771–84. https://doi.org/10.1016/S0140-6736(11)60993-8. - PMC - PubMed

LinkOut - more resources