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. 2019 Feb 6;6(3):ofz061.
doi: 10.1093/ofid/ofz061. eCollection 2019 Mar.

Indirect Effect of Azithromycin Use on the Intestinal Microbiome Diversity of Untreated Children: A Randomized Trial

Catherine E Oldenburg  1   2   3 , Ali Sié  4 , Boubacar Coulibaly  4 , Lucienne Ouermi  4 , Clarisse Dah  4 , Charlemagne Tapsoba  4 , Till Bärnighausen  5   6   7 , Elodie Lebas  1 , Ahmed M Arzika  8 , Susie Cummings  1 , Lina Zhong  1 , Thomas M Lietman  1   2   3 , Jeremy D Keenan  1   2   3 , Thuy Doan  1   2
Affiliations

Indirect Effect of Azithromycin Use on the Intestinal Microbiome Diversity of Untreated Children: A Randomized Trial

Catherine E Oldenburg et al. Open Forum Infect Dis. .

Erratum in

  • Correction.
    [No authors listed] [No authors listed] Open Forum Infect Dis. 2023 Oct 6;10(10):ofad489. doi: 10.1093/ofid/ofad489. eCollection 2023 Oct. Open Forum Infect Dis. 2023. PMID: 37818341 Free PMC article.

Abstract

Cohabiting children may share components of their intestinal microbiome. We evaluated whether receipt of azithromycin in one sibling confers changes to the intestinal microbiome in an untreated sibling compared with placebo in a randomized controlled trial. We found no evidence of an indirect effect of antibiotic use in cohabiting children. Clinical Trials Registrations: NCT03187834.

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Figures

Figure 1.
Figure 1.
Posttreatment Simpson (A) and Shannon (B) diversity of gut bacteria in untreated siblings of children treated with azithromycin (red line) or placebo (black line).
See this image and copyright information in PMC

References

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    1. Oldenburg CE, Sie A, Coulibaly B, et al. Effect of commonly-used pediatric antibiotics on gut microbial diversity in preschool children in Burkina Faso: a randomized clinical trial. Open Forum Infect Dis 2018; 5:ofy289. - PMC - PubMed
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