Why structure matters
- PMID: 30895925
- PMCID: PMC6428565
- DOI: 10.7554/eLife.45380
Why structure matters
Abstract
Great care is needed when interpreting claims about the genetic basis of human variation based on data from genome-wide association studies.
Keywords: GWAS; evolutionary biology; genetics; genomics; human; polygenic adaptation; population genetics; population structure; quantitative genetics; selection for human height.
© 2019, Barton et al.
Conflict of interest statement
NB, JH, MN No competing interests declared
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Comment on
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Reduced signal for polygenic adaptation of height in UK Biobank.Elife. 2019 Mar 21;8:e39725. doi: 10.7554/eLife.39725. Elife. 2019. PMID: 30895923 Free PMC article.
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Polygenic adaptation on height is overestimated due to uncorrected stratification in genome-wide association studies.Elife. 2019 Mar 21;8:e39702. doi: 10.7554/eLife.39702. Elife. 2019. PMID: 30895926 Free PMC article.
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