doi: 10.1039/c8cc10263e.
2,7-Diazabicyclo[2.2.1]heptanes: novel asymmetric access and controlled bridge-opening
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- PMID: 30895973
- DOI: 10.1039/c8cc10263e
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2,7-Diazabicyclo[2.2.1]heptanes: novel asymmetric access and controlled bridge-opening
Chem Commun (Camb).
.
Abstract
Organocatalysed asymmetric Michael additions of substituted triketopiperazines to enones afford products in high yield and enantiomeric ratio (er). Further modification delivers products possessing natural product (NP) scaffolds including diazabicyclo[2.2.1]heptane, prolinamide and harmicine.
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