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. 2019 Apr 4;55(29):4214-4217.
doi: 10.1039/c8cc10263e.

2,7-Diazabicyclo[2.2.1]heptanes: novel asymmetric access and controlled bridge-opening

Gary R Peczkowski  1 , Philip G E Craven, Darren Stead, Nigel S Simpkins
Affiliations

2,7-Diazabicyclo[2.2.1]heptanes: novel asymmetric access and controlled bridge-opening

Gary R Peczkowski et al. Chem Commun (Camb). .

Abstract

Organocatalysed asymmetric Michael additions of substituted triketopiperazines to enones afford products in high yield and enantiomeric ratio (er). Further modification delivers products possessing natural product (NP) scaffolds including diazabicyclo[2.2.1]heptane, prolinamide and harmicine.

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