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Randomized Controlled Trial
. 2019 Mar;98(12):e14918.
doi: 10.1097/MD.0000000000014918.

A randomized controlled trial on the effectiveness of 8-week high-intensity interval exercise on intrahepatic triglycerides, visceral lipids, and health-related quality of life in diabetic obese patients with nonalcoholic fatty liver disease

Walid Kamal Abdelbasset  1   2 , Sayed A Tantawy  3   4 , Dalia M Kamel  3   5 , Bader A Alqahtani  1 , Gaber S Soliman  6   7
Affiliations
Randomized Controlled Trial

A randomized controlled trial on the effectiveness of 8-week high-intensity interval exercise on intrahepatic triglycerides, visceral lipids, and health-related quality of life in diabetic obese patients with nonalcoholic fatty liver disease

Walid Kamal Abdelbasset et al. Medicine (Baltimore). 2019 Mar.

Erratum in

  • Erratum.
    [No authors listed] [No authors listed] Medicine (Baltimore). 2020 Sep 11;99(37):e22388. doi: 10.1097/MD.0000000000022388. Medicine (Baltimore). 2020. PMID: 32925802 Free PMC article. No abstract available.

Expression of concern in

  • Statement of Concern.
    [No authors listed] [No authors listed] Medicine (Baltimore). 2020 Jul 17;99(29):e21299. doi: 10.1097/MD.0000000000021299. Medicine (Baltimore). 2020. PMID: 33725806 Free PMC article. No abstract available.

Abstract

Background: Medications are limited for patients with nonalcoholic fatty liver disease (NAFLD). It has been reported that aerobic exercise is effective in reducing the characteristics of NAFLD, although unclear data have ascertained the effects of high-intensity interval aerobic exercise on health-related quality of life (HRQoL) in diabetic obese patients with NAFLD.

Objectives: This a randomized controlled trial aimed to ascertain the effectiveness of 8-week high-intensity interval exercise on intrahepatic triglycerides (IHTG), visceral lipids and HRQoL in diabetic obese patients with NAFLD.

Study design: Between August and December 2017, 32 diabetic obese patients with NAFLD aged 45 to 60 years (21 men and 11 women) were enrolled in this study. They were randomly assigned to 2 groups, 16 patients in each group, high-intensity interval (HII) exercise and control groups. The HII group received a program of HII aerobic exercise for 8 weeks with medications of NAFLD and the control group received only medications without any type of exercise intervention. The test of IHTG, visceral lipids, and HRQoL were recorded at the initial assessment and at the end of the program after 8 weeks.

Results: There were significant differences between the 2 groups at the end of the study. These study findings exhibited significant improvements in IHTG, VO2peak, visceral lipids, glycohemoglobin, plasma glucose, and all dimensions of HRQoL in the HII group (P <.05), But there was non-significant improvement in any measure in the control group (P >.05) after the 8-week intervention.

Conclusion: Eight-week high-intensity interval aerobic exercise has a beneficial effect on IHTG, visceral lipids, and HRQoL in diabetic obese patients with NAFLD. Effort and awareness should be dedicated to encouraging the active lifestyle among different population, especially diabetic obese patients with NAFLD.

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Conflict of interest statement

The authors declare that they do not have any conflicts of interest.

Figures

Figure 1
Figure 1
Flow diagram showing the patients who participated in the study.
See this image and copyright information in PMC

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References

    1. Dunn W, Xu R, Wingard DL, et al. Suspected nonalcoholic fatty liver disease and mortality risk in a population-based cohort study. Am J Gastroenterol 2008;103:2263–71. - PMC - PubMed
    1. Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA 2002;287:356–9. - PubMed
    1. Pi-Sunyer FX. The obesity epidemic: pathophysiology and consequences of obesity. Obes Res 2002;10suppl 2:97S–104S. - PubMed
    1. McMillan KP, Kuk JL, Church TS, et al. Independent associations between liver fat, visceral adipose tissue, and metabolic risk factors in men. Appl Physiol Nutr Metab 2007;32:265–72. - PubMed
    1. Younossi ZM, Gramlich T, Matteoni CA, et al. Nonalcoholic fatty liver disease in patients with type 2 diabetes. Clin Gastroenterol Hepatol 2004;2:262–5. - PubMed

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