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. 1986 Jul 15;158(2):295-8.
doi: 10.1111/j.1432-1033.1986.tb09750.x.

Primary structure of a new tetraantennary glycan of the N-acetyllactosaminic type isolated from human factor VIII/von Willebrand factor

B Samor, J C Michalski, H Debray, C Mazurier, M Goudemand, H Van Halbeek, J F Vliegenthart, J Montreuil
Free article

Primary structure of a new tetraantennary glycan of the N-acetyllactosaminic type isolated from human factor VIII/von Willebrand factor

B Samor et al. Eur J Biochem. .
Free article

Abstract

N-Glycosidically linked glycopeptides released by mild alkaline treatment of human factor VIII/von Willebrand factor (FVIII/vWF) were fractionated by serial affinity chromatography on columns of Sepharose linked to concanavalin A (ConA) and Lens culinaris agglutinin (LCA). The fraction which is not retained on ConA-Sepharose, but eluted from LCA-Sepharose contains a pure minor glycopeptide which was structurally analysed. Based on the results of methylation analysis and 500-MHz 1H-NMR spectroscopy, the following structure is proposed: (Formula: see text).

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