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. 2019 Mar 20;9(3):e024731.
doi: 10.1136/bmjopen-2018-024731.

Associations between lipid profiles of adolescents and their mothers based on a nationwide health and nutrition survey in South Korea

Ji Hyung Nam  1   2 , Jaeyong Shin  3 , Sung-In Jang  3 , Ji Hyun Kim  4 , Kyu-Tae Han  5 , Jun Kyu Lee  1 , Yun Jeong Lim  1 , Eun-Cheol Park  3
Affiliations

Associations between lipid profiles of adolescents and their mothers based on a nationwide health and nutrition survey in South Korea

Ji Hyung Nam et al. BMJ Open. .

Abstract

Objectives: Dyslipidaemia is a metabolic disease influenced by environmental and genetic factors. Especially, family history related to genetic background is a strong risk factor of lipid abnormality. The aim of this study is to evaluate the association between the lipid profiles of adolescents and their mothers.

Design: A cross-sectional study.

Setting: The data were derived from the Korea National Health and Nutrition Examination Survey (IV-VI) between 2009 and 2015.

Participants: 2884 adolescents aged 12-18 years and their mothers were included.

Primary outcome measures: Outcome variables were adolescents' lipid levels. Mothers' lipid levels were the interesting variables. The lipid profiles included total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). We identified partial correlation coefficients (r) between the lipids. Multiple linear regressions were performed to identify the amount of change in adolescents' lipid levels for each unit increase of their mothers' lipids. The regression models included various clinical characteristics and health behavioural factors of both adolescents and mothers.

Results: The mean levels of adolescents' lipids were 156.6, 83.6, 50.4 and 89.4 mg/dL, respectively for TC, TG, HDL-C and LDL-C. Positive correlations between lipid levels of adolescents and mothers were observed for TC, TG, HDL-C and LDL-C (r, 95% CI: 0.271, 0.236 to 0.304; 0.204, 0.169 to 0.239; 0.289, 0.255 to 0.322; and 0.286, 0.252 to 0.319). The adolescent TC level was increased by 0.23 mg/dL for each unit increase of the mother's TC (SE, 0.02; p<0.001). The beta coefficients were 0.16 (SE, 0.01), 0.24 (SE, 0.02) and 0.24 (SE, 0.02), respectively, in each model of TG, HDL-C and LDL-C (all p<0.001). The linear relationships were significant regardless of sex and mother's characteristics.

Conclusions: Mothers' lipid levels are associated with adolescents' lipids; therefore, they can serve as a reference for the screening of adolescent's dyslipidaemia.

Keywords: adolescent; cholesterol; dyslipidemia; lipids; mother.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Study flow showing sample selection. We selected 2884 adolescents aged 12–18 whose mothers’ data were also available.
Figure 2
Figure 2
Bar graphs showing standardised beta coefficients of adolescents' lipids for each unit increase in their mothers' lipids in subgroups. BMI, body mass index; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; TC, total cholesterol; TG, triglyceride.
See this image and copyright information in PMC

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