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Case Reports
. 1986 Jul;73(3):189-92.
doi: 10.1007/BF00401225.

Altered cellular response to UV irradiation in a patient affected by premature ageing

M Stefanini, G Orecchia, G Rabbiosi, F Nuzzo
Case Reports

Altered cellular response to UV irradiation in a patient affected by premature ageing

M Stefanini et al. Hum Genet. 1986 Jul.

Abstract

An abnormal response to UV-irradiation was found in a patient affected by precocious senescence. A decreased level of unscheduled DNA synthesis (UDS) was present in 60% of Go lymphocytes and in fibroblasts after the fifth culture passage. Hypersensitivity of lymphocytes to UV-light was indicated also by a decreased rate of DNA synthesis after mitogen stimulation. The results of this study indicate that the defect which determines the premature ageing influences the capacity to repair UV-induced DNA damage.

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