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Review
. 2019 Mar;15(2):275-283.
doi: 10.5114/aoms.2018.75638. Epub 2018 May 15.

Association between circulating leptin concentration and G-2548A gene polymorphism in patients with breast cancer: a meta-analysis

Ji-Qing Hao  1 , Qian-Kun Zhang  1 , Yi-Xin Zhou  1 , Li-Hao Chen  1 , Peng-Fei Wu  1
Affiliations
Review

Association between circulating leptin concentration and G-2548A gene polymorphism in patients with breast cancer: a meta-analysis

Ji-Qing Hao et al. Arch Med Sci. 2019 Mar.

Abstract

Introduction: The aim of this meta-analysis was to summarize the evidence on the serum/plasma leptin concentrations in breast cancer (BC) patients, as well as the associations between leptin G-2548A gene polymorphisms and susceptibility to BC.

Material and methods: Potentially relevant studies about serum/plasma leptin levels and leptin G-2548A gene polymorphism were selected using the electronic databases PubMed, EMBASE and The Cochrane Library (from January 1 1995 to Jun 30 2017, no language restrictions). The potential sources of heterogeneity were assessed by the Q statistic and quantified using I2 ; publication bias was qualitatively assessed by funnel plot and quantitatively assessed by Egger's linear regression test.

Results: A total of 1141 articles were retrieved after database searches, and 27 studies with 9516 subjects (4542 BC patients/4974 controls) were finally included. The results indicated that BC patients had significantly higher leptin levels compared with healthy controls (SMD = 1.65, 95% CI: 1.21-2.09, p < 0.001), but there was no association between leptin G-2548A polymorphism and BC (OR = 1.05, 95% CI: 0.80-1.39, p = 0.722). Subgroup analyses demonstrated increased leptin levels in BC patients of different region, race, body mass index and waist circumference.

Conclusions: Our results revealed a significantly higher leptin level in BC patients than in healthy controls, but no association between leptin G-2548A polymorphism and BC susceptibility was found.

Keywords: breast cancer; gene polymorphism; leptin; meta-analysis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flowchart of selected articles
Figure 2
Figure 2
Meta-analysis of 21 studies reporting on leptin in BC patients compared with controls
Figure 3
Figure 3
ORs and 95% CI of individual studies and pooled data for the allelic associations between the leptin G-2548A gene polymorphism and BC
Figure 4
Figure 4
Funnel plot (with pseudo 95% confidence intervals) with the standard error of the leptin difference plotted against the mean difference of leptin of each study (A); Filled funnel plot (with pseudo 95% confidence intervals) with the standard error of the leptin difference plotted against the mean difference of leptin of each study (B)
Figure 5
Figure 5
Funnel plot of 7 studies regarding the association between the leptin G-2548A allele and BC in all subjects
See this image and copyright information in PMC

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