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Editorial
. 2019 Feb 22;10(16):1546-1548.
doi: 10.18632/oncotarget.26688.

TERT promoter mutations in melanoma survival

Eduardo Nagore  1 , Sivaramakrishna Rachakonda  1   2 , Rajiv Kumar  2
Affiliations
Editorial

TERT promoter mutations in melanoma survival

Eduardo Nagore et al. Oncotarget. .
No abstract available

Keywords: TERT promoter; melanoma; mutations; prognostic; survival.

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Figures

Figure 1
Figure 1. Schematic representation of the TERT promoter mutations
The mutations at the -57, -124, -138/-139 and -146 bp position from ATG start site of the TERT gene create CCGGAA/T consensus sites for ETS transcription factors. The binding of the ETS transcription factors in conjunction with preexisting native ETS sites in the proximity causes epigenetic transformations and recruitment of pol II leading to mono-allelic TERT expression. The variant allele of the polymorphism represented by rs2853669 at the -245 bp position abrogates the preexisting non-canonical ETS2 site.
See this image and copyright information in PMC

References

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