Management of a chronic radiation necrosis wound with lyopreserved placental membrane containing viable cells

Abstract

This case report describes management of a chronic radiation wound in a patient with multiple comorbidities using a lyopreserved placental membrane containing viable cells (vLPM). Positive outcomes suggest that vLPM provides a good conservative management option for patients with compromised wound healing due to radiation and comorbidities.

Keywords: lyopreserved; placental membrane; radiation necrosis; viable; wound.

Figure 1

(A‐H) Progression of the wound 10 mo prior to vLPM treatment until complete closure at day 98

Figure 2

Changes in wound size during vLPM adjunct to standard of care (SOC) treatment course. Wound size at each time point is presented in % of wound area relative to the baseline. Baseline was defined as the first day of vLPM application and is marked as day 0 on the X‐axis. Visits when the patient was treated with vLPM plus SOC are represented by black circle markers on the graph. Visits when the patient was treated with SOC alone are shown with black square markers. Note: The patient received 12 applications of vLPM; however, measurements were not obtained at one visit on day 77