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Case Reports
. 2019 Jan 31;7(3):482-485.
doi: 10.1002/ccr3.2019. eCollection 2019 Mar.

Use of botulinum toxin in Frey's syndrome

Affiliations
Case Reports

Use of botulinum toxin in Frey's syndrome

Francesco Freni et al. Clin Case Rep. .

Abstract

Frey's syndrome is the most common adverse event after parotidectomy, and usually, it appears after 6 months. In our case, symptoms appear 20 years from surgery, an uncommon condition. Intralesional botulinum toxin gives excellent results in therapy, regardless of the time elapsed between surgery and the first treatment.

Keywords: Frey syndrome; Mikulicz syndrome; Minor test; Sjogren syndrome; botulinum toxin; parotidectomy.

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Conflict of interest statement

None declared.

Figures

Figure 1
Figure 1
Minor test, the starch powder was applied on the dried iodine covered area
Figure 2
Figure 2
Minor test positive, brown‐violet areas appear on the skin
Figure 3
Figure 3
The area was subdivided into squares of 1 cm2 for a better distribution of the drug

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References

    1. Linder TE, Huber A, Schmid S. Frey’s syndrome after parotidectomy: a retrospective and prospective analysis. Laryngoscope. 1997;107:1496‐1501. - PubMed
    1. Ford FR, Woodhall R. Phenomena due to misdirection of regenerating fibres of cranial, spinal and automatic nerves, clinical observations. Arch Surg. 1938;36:480‐496.
    1. Tugnoli V, Marchese Ragona R, Eleopra R, et al. The role of gustatory flushing in Frey’s syndrome and its treatment with botulinum toxin type A. Clin Auton Res. 2002;12:174‐178. - PubMed
    1. Xie S, Wang K, Xu T, Guo XS, Shan XF, Cai ZG. Efficacy and safety of botulinum toxin type A for treatment of Frey's syndrome: evidence from 22 published articles. Cancer Med. 2015;4(11):1639‐1650. - PMC - PubMed
    1. Galletti B, Gazia F, Freni F, Sireci F, Galletti F. Endoscopic sinus surgery with and without computer assisted navigation: A retrospective study. Auris Nasus Larynx. 2018. - PubMed

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