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Case Reports
. 2019 Mar 14:7:2050313X19836583.
doi: 10.1177/2050313X19836583. eCollection 2019.

Granulomatous lobular mastitis associated with ductal carcinoma in situ of the breast

David Oddó  1 , Francisco Domínguez  2 , Natalia Gómez  1 , Gonzalo P Méndez  1 , María Elena Navarro  3
Affiliations
Case Reports

Granulomatous lobular mastitis associated with ductal carcinoma in situ of the breast

David Oddó et al. SAGE Open Med Case Rep. .

Abstract

The association of granulomatous lobular mastitis and carcinoma of the breast is very infrequent. We present the case of a 44-year-old woman with concurrent granulomatous lobular mastitis with coryneform bacteria and ductal carcinoma in situ in the same breast.

Keywords: Granulomatous lobular mastitis; breast; coryneform bacteria; ductal carcinoma in situ.

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Conflict of interest statement

Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
(a) Breast ultrasound shows left breast with cutaneous thickening, increasing echogenicity of subcutaneous tissue, superficial laminar collection, loss of fatty planes, and multiple anfractuous collections. (b) Percutaneous biopsy under ultrasound vision shows puncture needle (linear echogenic image) in collection area. (c) Ultrasound control shows no significant changes with respect to inflammatory changes. There is an anfractuous collection in the union of both outer quadrants of the left breast. (d) Digital mammography (localized and magnified plate) shows a diffuse dense breast with focal areas of higher density, related to areas of collections with no evident microcalcifications.
Figure 2.
Figure 2.
Core biopsy of the breast. Note the multifocal distribution of the lesions; there are multiple foci of granulomatous lobular mastitis (blue arrows) and areas with ductal carcinoma in situ (red arrows) (hematoxylin–eosin 4×, original magnification).
Figure 3.
Figure 3.
Core biopsy of the breast. (a) Granulomatous lobular mastitis (hematoxylin–eosin 10×, original magnification). (b) Coryneform bacteria in granulomatous lobular mastitis (Gram stain 40×, original magnification). (c) and (d) Solid ductal carcinoma in situ (hematoxylin–eosin 10× and 40×, respectively, original magnification).
Figure 4.
Figure 4.
Surgical biopsy of the breast. (a) Skin (S) and breast tissue (BT). There are two areas with ductal carcinoma in situ (red arrows) and an area of granulomatous lobular mastitis (blue arrow) (hematoxylin–eosin 4×, original magnification). (b) Ductal carcinoma in situ (red arrows) coalescent with granulomatous lobular mastitis (blue arrow) (hematoxylin–eosin 10×, original magnification).
See this image and copyright information in PMC

References

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