The impact of decreasing biodiversity on novel drug discovery: is there a serious cause for concern?

Abstract

The aim of this perspective is to discuss the current and potential situation concerning the loss of biodiversity and its current and potential effects upon the search for novel bioactive agents from natural sources, be they from marine, microbial or terrestrial environments. Areas covered: Herein, the author covers terrestrial plants, marine organisms (but not vertebrates), and unicellular microbes from both terrestrial and marine sources. The emphasis is on the unknown effects of biodiversity perturbation and/or loss of microbes that are now realized to underlie the production of a significant number of natural products, whether they were first found in plants or marine invertebrates. Expert opinion: From the discussion of the areas above comes the realization that we do not know what we still have. Furthermore, we cannot measure, other than in very gross terms, what we have lost. Thus, deciding how, and where geographically, one should now search for novel bioactive agents is a major and continuing problem.

Keywords: Biodiversity loss; bioactive compounds; microbes; plants; uncultivated microbes.