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Review
. 2019 Mar 22;476(6):931-950.
doi: 10.1042/BCJ20190022.

The DCBLD receptor family: emerging signaling roles in development, homeostasis and disease

Anna M Schmoker  1 , Alicia M Ebert  2 , Bryan A Ballif  1
Affiliations
Review

The DCBLD receptor family: emerging signaling roles in development, homeostasis and disease

Anna M Schmoker et al. Biochem J. .

Abstract

The discoidin, CUB, and LCCL domain-containing (DCBLD) receptor family are composed of the type-I transmembrane proteins DCBLD1 and DCBLD2 (also ESDN and CLCP1). These proteins are highly conserved across vertebrates and possess similar domain structure to that of neuropilins, which act as critical co-receptors in developmental processes. Although DCBLD1 remains largely uncharacterized, the functional and mechanistic roles of DCBLD2 are emerging. This review provides a comprehensive discussion of this presumed receptor family, ranging from structural and signaling aspects to their associations with cancer, physiology, and development.

Keywords: DCBLD1; DCBLD2; cancer; cell signaling; development; signal transduction.

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