Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Sep;13(3):291-301.
doi: 10.1007/s12079-019-00511-z. Epub 2019 Mar 22.

The endothelial tip-stalk cell selection and shuffling during angiogenesis

Wenqi Chen  1 , Peng Xia  2 , Heping Wang  3 , Jihao Tu  1 , Xinyue Liang  4 , Xiaoling Zhang  5   6 , Lisha Li  7
Affiliations
Review

The endothelial tip-stalk cell selection and shuffling during angiogenesis

Wenqi Chen et al. J Cell Commun Signal. 2019 Sep.

Abstract

Angiogenesis is a critical, fine-tuned, multi-staged biological process. Tip-stalk cell selection and shuffling are the building blocks of sprouting angiogenesis. Accumulated evidences show that tip-stalk cell selection and shuffling are regulated by a variety of physical, chemical and biological factors, especially the interaction among multiple genes, their products and environments. The classic Notch-VEGFR, Slit-Robo, ECM-binding integrin, semaphorin and CCN family play important roles in tip-stalk cell selection and shuffling. In this review, we outline the progress and prospect in the mechanism and the roles of the various molecules and related signaling pathways in endothelial tip-stalk cell selection and shuffling. In the future, the regulators of tip-stalk cell selection and shuffling would be the potential markers and targets for angiogenesis.

Keywords: Angiogenesis; Endothelial cells; Signaling pathway; Tip-stalk cell selection; Tip-stalk shuffling.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there are no conflicts of interest.

Figures

Fig. 1
Fig. 1
Tip-stalk cell selection and shuffling
Fig. 2
Fig. 2
Influencing factors of tip-stalk cell selection and shuffling
Fig. 3
Fig. 3
The signaling pathways are connected to form a sophisticated network to regulating tip selection during angiogenesis
See this image and copyright information in PMC

References

    1. Adada MM, et al. Intracellular sphingosine kinase 2-derived sphingosine-1-phosphate mediates epidermal growth factor-induced ezrin-radixin-moesin phosphorylation and cancer cell invasion. FASEB J. 2015;29(11):4654–4669. - PMC - PubMed
    1. Adam MG, et al. Synaptojanin-2 binding protein stabilizes the notch ligands DLL1 and DLL4 and inhibits sprouting angiogenesis. Circ Res. 2013;113(11):1206–1218. - PubMed
    1. Adams RH, Alitalo K. Molecular regulation of angiogenesis and lymphangiogenesis. Nat Rev Mol Cell Biol. 2007;8(6):464–478. - PubMed
    1. Basile JR, Gavard J, Gutkind JS. Plexin-B1 utilizes RhoA and rho kinase to promote the integrin-dependent activation of Akt and ERK and endothelial cell motility. J Biol Chem. 2007;282(48):34888–34895. - PubMed
    1. Belair DG, et al. Human iPSC-derived endothelial cell sprouting assay in synthetic hydrogel arrays. Acta Biomater. 2016;39:12–24. - PMC - PubMed

LinkOut - more resources