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. 1986 Aug 18;39(7):645-50.
doi: 10.1016/0024-3205(86)90046-9.

Inhibition of mammalian digestive disaccharidases by polyhydroxy alkaloids

A M Scofield, L E Fellows, R J Nash, G W Fleet

Inhibition of mammalian digestive disaccharidases by polyhydroxy alkaloids

A M Scofield et al. Life Sci. .

Abstract

Several polyhydroxy alkaloids, including the eight presently known to occur in plants, have been compared as inhibitors of mouse gut digestive disaccharidases. The indolizidine castanospermine inhibited all activities tested, but others showed a selectivity which could be of value in studies of carbohydrate digestion and errors of metabolism.

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