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. 2019 Apr;95(4):736-738.
doi: 10.1016/j.kint.2018.12.004.

Don't trick me twice!

Wulf Tonnus  1 , Alexia Belavgeni  1 , Yanfang Xu  2 , Andreas Linkermann  3
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Don't trick me twice!

Wulf Tonnus et al. Kidney Int. 2019 Apr.
Free article

Abstract

Chemotherapy-induced nephrotoxicity limits the success of cancer therapy. Landau et al. now describe a mechanism by which a first dose of cisplatin renders the kidney sensitive to necroptosis mediated by a second dose. Unresolved injury and sustained necrosis, therefore, may represent a pathophysiological means of transition from acute kidney injury to chronic kidney disease.

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