[Treatment of patients with brain metastases from a melanoma]

Abstract

Whereas immune checkpoint inhibitors of serine/threonine protein kinase B-raf therapy dramatically changed metastatic outcomes of patients with melanoma, they remain at high risk of brain extension. Additional local treatment can be offered in this situation such as surgery and or stereotactic radiotherapy. In this review article, we describe the different options with published data and their optimal timing.

Keywords: Anti-BRAF treatment; Brain metastases; Chirurgie; Immune check point inhibitors; Immunothérapie; Metastatic melanoma; Mélanome métastatique; Métastases cérébrales; Radiothérapie; Stereotactic radiotherapy; Stéréotaxie.