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. 2019 Mar;10(3):147-155.
doi: 10.3892/br.2019.1188. Epub 2019 Jan 25.

Aberrant mRNA splicing generates oncogenic RNA isoforms and contributes to the development and progression of cholangiocarcinoma

Juthamas Yosudjai  1 , Sopit Wongkham  2 , Siwanon Jirawatnotai  3 , Worasak Kaewkong  1
Affiliations

Aberrant mRNA splicing generates oncogenic RNA isoforms and contributes to the development and progression of cholangiocarcinoma

Juthamas Yosudjai et al. Biomed Rep. 2019 Mar.

Abstract

Cholangiocarcinoma is a lethal biliary cancer, with an unclear molecular pathogenesis. Alternative splicing is a post-transcriptional modification that generates mature mRNAs, which are subsequently translated into proteins. Aberrant alternative splicing has been reported to serve a role in tumor initiation, maintenance and metastasis in several types of human cancer, including cholangiocarcinoma. In this review, the aberrant splicing of genes and the functional contributions of the spliced genes, in the carcinogenesis, progression and aggressiveness of cholangiocarcinoma are summarized. In addition, factors that influence this aberrant splicing that may be relevant as therapeutic targets or prognosis markers for cholangiocarcinoma are discussed.

Keywords: alternative splicing; cholangiocarcinoma; spliced gene.

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Figures

Figure 1.
Figure 1.
Schematic representation of the alternative splicing events implicated in cholangiocarcinoma development and progression. Exons are represented by boxes and introns by lines. Continuous lines represent the exon inclusion for wild-type mRNA, whereas dotted lines represent the exon inclusion for spliced transcripts. Skipped or included exons from alternative splicing, that differ from wild-type mRNA, are presented in gray
Figure 2.
Figure 2.
Spliced mRNA transcripts and their functions in cholangiocarcinoma.
See this image and copyright information in PMC

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