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Comment
. 2016 Sep;5(Suppl 3):S536-S539.
doi: 10.21037/tcr.2016.08.24.

Colonic crypts are natural gatekeepers of microbial metabolites to protect stem cells

Praveen Kumar Vemula  1   2 , Venkatakrishna Rao Jala  3
Affiliations
Comment

Colonic crypts are natural gatekeepers of microbial metabolites to protect stem cells

Praveen Kumar Vemula et al. Transl Cancer Res. 2016 Sep.
No abstract available

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Conflict of interest statement

Conflicts of Interest: The authors have no confiicts of interest to declare.

Figures

Figure 1
Figure 1
Crypts protect stem/progenitor cells from microbial metabolite butyrate anti-proliferative activities. The model representing the colon crypt epithelial cells act as natural filters for channeling the microbial metabolite butyrate. In healthy colonic environment, epithelial cells from the top of crypts metabolize specifically butyrate (but not acetate, propionate) through Acyl-CoA Dehydrogenase (ACADs) leading to reduced levels of butyrate at the bottom of crypt. Decreased levels of butyrate do not display its anti-proliferative activities on residing stem/progenitor cells at the bottom of crypt. The colonic injury or dysbiosis condition (absence of crypts) leads to uncontrolled exposure of metabolites consisting of butyrate suppress the proliferation of stem/progenitor cells through blocking activities of histone deacetylases (HDACs).
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Comment on

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