Emerging roles of lncRNAs in the post-transcriptional regulation in cancer

doi:10.1016/j.gendis.2019.01.003

Review

. 2019 Feb 11;6(1):6-15.

doi: 10.1016/j.gendis.2019.01.003. eCollection 2019 Mar.

Emerging roles of lncRNAs in the post-transcriptional regulation in cancer

Rong-Zhang He^{1

2

3}, Di-Xian Luo², Yin-Yuan Mo³

Affiliations

¹ Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410078 Hunan, China.
² Translational Medicine Institute, National & Local Joint Engineering Laboratory for High-through Molecular Diagnosis Technology, Collaborative Research Center for Post-doctoral Mobile Stations of Central South University, Affiliated the First People's Hospital of Chenzhou of University of South China, Chenzhou, 432000, China.
³ Department of Pharmacology/Toxicology, and Cancer Institute, University of Mississippi Medical Center, Jackson, MS, USA.

PMID: 30906827
PMCID: PMC6411652
DOI: 10.1016/j.gendis.2019.01.003

Review

Emerging roles of lncRNAs in the post-transcriptional regulation in cancer

Rong-Zhang He et al. Genes Dis. 2019.

. 2019 Feb 11;6(1):6-15.

doi: 10.1016/j.gendis.2019.01.003. eCollection 2019 Mar.

Authors

Rong-Zhang He^{1

2

3}, Di-Xian Luo², Yin-Yuan Mo³

Affiliations

¹ Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410078 Hunan, China.
² Translational Medicine Institute, National & Local Joint Engineering Laboratory for High-through Molecular Diagnosis Technology, Collaborative Research Center for Post-doctoral Mobile Stations of Central South University, Affiliated the First People's Hospital of Chenzhou of University of South China, Chenzhou, 432000, China.
³ Department of Pharmacology/Toxicology, and Cancer Institute, University of Mississippi Medical Center, Jackson, MS, USA.

PMID: 30906827
PMCID: PMC6411652
DOI: 10.1016/j.gendis.2019.01.003

Abstract

Accumulating evidence indicates that long non-coding RNAs (lncRNAs) can play a pivotal role in regulation of diverse cellular processes. In particular, lncRNAs can serve as master gene regulators at transcriptional and posttranscriptional levels, leading to tumorigenesis. In this review, we discuss latest developments in lncRNA-meditated gene expression at the post-transcriptional level, including gene splicing, mRNA stability, protein stability and nuclear trafficking.

Keywords: Alternative splicing; LncRNA; Posttranscriptional regulation; Protein stability; RNA binding proteins; RNA stability.

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Figures

**Fig. 1**
**A simplified model for lncRNA-mediated alternative splicing**. A, LncRNA promotes inclusion of Exon2 (E2) by interaction with enhancing splicing factor (SF-e) to form splicing variant 1 (SV-1). B, LncRNA promotes skipping of Exon2 (E2) by interaction with silencing splicing factor (SF-s) to form splicing variant 2 (SV-2).

**Fig. 2**
**LncRNAs serve as positive or negative regulator through interaction with RNA binding proteins (RBPs)**. A, Binding of lncRNA to 3-UTR facilitates recruiting RBPs. B, Binding of lncRNA to 3-UTR prevents RBP interaction with 3′-UTR. RBP-d, destabilizing RBP; RBP-s, stabilizing RBP.

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References

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[1] Birney E., Stamatoyannopoulos J.A., Dutta A. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature. 2007;447(7146):799–816. - PMC - PubMed

[2] Birney E., Stamatoyannopoulos J.A., Dutta A. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature. 2007;447(7146):799–816. - PMC - PubMed

[3] Kapranov P., Willingham A.T., Gingeras T.R. Genome-wide transcription and the implications for genomic organization. Nat Rev Genet. 2007;8(6):413–423. - PubMed

[4] Kapranov P., Willingham A.T., Gingeras T.R. Genome-wide transcription and the implications for genomic organization. Nat Rev Genet. 2007;8(6):413–423. - PubMed

[5] Gibb E.A., Brown C.J., Lam W.L. The functional role of long non-coding RNA in human carcinomas. Mol Cancer. 2011;10:38. - PMC - PubMed

[6] Gibb E.A., Brown C.J., Lam W.L. The functional role of long non-coding RNA in human carcinomas. Mol Cancer. 2011;10:38. - PMC - PubMed

[7] Esteller M. Non-coding RNAs in human disease. Nat Rev Genet. 2011;12(12):861–874. - PubMed

[8] Esteller M. Non-coding RNAs in human disease. Nat Rev Genet. 2011;12(12):861–874. - PubMed

[9] Wilusz J.E. Long noncoding RNAs: Re-writing dogmas of RNA processing and stability. Biochim Biophys Acta. 2016;1859(1):128–138. - PMC - PubMed

[10] Wilusz J.E. Long noncoding RNAs: Re-writing dogmas of RNA processing and stability. Biochim Biophys Acta. 2016;1859(1):128–138. - PMC - PubMed

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Emerging roles of lncRNAs in the post-transcriptional regulation in cancer

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Emerging roles of lncRNAs in the post-transcriptional regulation in cancer

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Abstract

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