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Review
. 2019 Feb 11;6(1):6-15.
doi: 10.1016/j.gendis.2019.01.003. eCollection 2019 Mar.

Emerging roles of lncRNAs in the post-transcriptional regulation in cancer

Rong-Zhang He  1   2   3 , Di-Xian Luo  2 , Yin-Yuan Mo  3
Affiliations
Review

Emerging roles of lncRNAs in the post-transcriptional regulation in cancer

Rong-Zhang He et al. Genes Dis. .

Abstract

Accumulating evidence indicates that long non-coding RNAs (lncRNAs) can play a pivotal role in regulation of diverse cellular processes. In particular, lncRNAs can serve as master gene regulators at transcriptional and posttranscriptional levels, leading to tumorigenesis. In this review, we discuss latest developments in lncRNA-meditated gene expression at the post-transcriptional level, including gene splicing, mRNA stability, protein stability and nuclear trafficking.

Keywords: Alternative splicing; LncRNA; Posttranscriptional regulation; Protein stability; RNA binding proteins; RNA stability.

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Figures

Fig. 1
Fig. 1
A simplified model for lncRNA-mediated alternative splicing. A, LncRNA promotes inclusion of Exon2 (E2) by interaction with enhancing splicing factor (SF-e) to form splicing variant 1 (SV-1). B, LncRNA promotes skipping of Exon2 (E2) by interaction with silencing splicing factor (SF-s) to form splicing variant 2 (SV-2).
Fig. 2
Fig. 2
LncRNAs serve as positive or negative regulator through interaction with RNA binding proteins (RBPs). A, Binding of lncRNA to 3-UTR facilitates recruiting RBPs. B, Binding of lncRNA to 3-UTR prevents RBP interaction with 3′-UTR. RBP-d, destabilizing RBP; RBP-s, stabilizing RBP.
See this image and copyright information in PMC

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