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Review
. 2019 Oct;25(11):1427-1433.
doi: 10.1177/1352458519837705. Epub 2019 Mar 25.

MOG antibody-associated encephalomyelitis/encephalitis

Sara Salama  1 , Majid Khan  2 , Santiago Pardo  3 , Izlem Izbudak  2 , Michael Levy  4
Affiliations
Review

MOG antibody-associated encephalomyelitis/encephalitis

Sara Salama et al. Mult Scler. 2019 Oct.

Abstract

Myelin oligodendrocyte glycoprotein (MOG) antibody disease is a rare autoimmune disorder with antibodies against the MOG predominantly involving the optic nerve and spinal cord leading to vision loss and paralysis. When MOG antibody disease involves the brain, the phenotype is similar to acute disseminated encephalomyelitis (ADEM). In this review, we discuss MOG-positive cases presenting with encephalitis, encephalopathy, or ADEM-like presentation based on recently published series.

Keywords: MOG antibody disease; MOG encephalomyelitis; MOG-EM; anti-MOG; myelin oligodendrocyte glycoprotein; optic neuritis; transverse myelitis.

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Conflict of interest statement

Disclosures: Authors have no disclosures to report that are applicable to this study.

Figures

Figure 1:
Figure 1:
Axial FLAIR, T2-weighted and post-contrast images showing cortical, juxta-cortical and deep white matter signal changes with nodular avid enhancement in a patient with MOG during the first attack (upper row) and during the second attack (lower row).
Figure 2:
Figure 2:
Axial FLAIR and post-contrast images showing cortical and juxta-cortical signal changes with associated avid enhancement [A, B] in a patient with MOG. Follow-up axial FLAIR image shows near complete resolution of signal changes [C].
See this image and copyright information in PMC

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