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Case Reports
. 2019 Aug;21(4):e13083.
doi: 10.1111/tid.13083. Epub 2019 May 11.

Native kidney BK virus nephropathy, a systematic review

Ankur Shah  1 , Vinayak Kumar  2 , Matthew B Palmer  2   3 , Jennifer Trofe-Clark  1   2   4 , Benjamin Laskin  2   5 , Deirdre Sawinski  1   2 , Jonathan J Hogan  1   2
Affiliations
Case Reports

Native kidney BK virus nephropathy, a systematic review

Ankur Shah et al. Transpl Infect Dis. 2019 Aug.

Abstract

Background: There is a growing base of literature describing BK nephropathy (BKVN) in patients outside of the setting of kidney transplant. Previous systematic reviews of the literature have been limited by methodology or by the scope of patients included.

Study design and methods: Systematic Review (Prospero # CRD42018088524).

Setting & population: Patients without kidney transplant who had biopsy-proven BKVN.

Selection criteria for studies: Full-text articles that describe native BKVN patient cases.

Analytical approach: Descriptive synthesis.

Results: The search identified 630 unique articles of which 51 were included in the final review. Sixty-five cases (including two new cases presented in this review) were identified, all but one occurred in the setting of known immunosuppression.

Limitations: The primary limitation was the exclusion of studies that did not fulfill the stringent review criteria. We excluded reports with only a clinical diagnosis of BKVN, such as those with viruria and/or viremia without biopsy.

Conclusions: As of May 2018, there are 65 reported cases of BKVN in native kidneys. This represents the most comprehensive description of biopsy-proven BKVN in native kidneys to date. Evaluation for BK nephropathy should be considered in immunocompromised patients who exhibit unexplained renal failure.

Keywords: BK Nephropathy; BK Virus; NRSOT; Tubulointerstitial nephritis; transplantation.

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Conflict of interest statement

CONFLICT OF INTEREST

The authors declared that they have no relevant financial interests.

Figures

FIGURE 1
FIGURE 1
Article screening process for systematic review
FIGURE 2
FIGURE 2
This diagram represents a breakdown of the primary medical issue faced by the native-kidney
See this image and copyright information in PMC

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