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. 2019 Mar 25;14(3):e0213809.
doi: 10.1371/journal.pone.0213809. eCollection 2019.

Estrogenic activity, race/ethnicity, and Indigenous American ancestry among San Francisco Bay Area women

Sylvia S Sanchez  1 , Phum Tachachartvanich  1 , Frank Z Stanczyk  2 , Scarlett L Gomez  3   4 , Esther M John  3 , Martyn T Smith  1 , Laura Fejerman  5
Affiliations

Estrogenic activity, race/ethnicity, and Indigenous American ancestry among San Francisco Bay Area women

Sylvia S Sanchez et al. PLoS One. .

Abstract

Estrogens play a significant role in breast cancer development and are not only produced endogenously, but are also mimicked by estrogen-like compounds from environmental exposures. We evaluated associations between estrogenic (E) activity, demographic factors and breast cancer risk factors in Non-Latina Black (NLB), Non-Latina White (NLW), and Latina women. We examined the association between E activity and Indigenous American (IA) ancestry in Latina women. Total E activity was measured with a bioassay in plasma samples of 503 women who served as controls in the San Francisco Bay Area Breast Cancer Study. In the univariate model that included all women with race/ethnicity as the independent predictor, Latinas had 13% lower E activity (p = 0.239) and NLBs had 35% higher activity (p = 0.04) compared to NLWs. In the multivariable model that adjusted for demographic factors, Latinas continued to show lower E activity levels (26%, p = 0.026), but the difference between NLBs and NLWs was no longer statistically significant (p = 0.431). An inverse association was observed between E activity and IA ancestry among Latina women (50% lower in 0% vs. 100% European ancestry, p = 0.027) consistent with our previously reported association between IA ancestry and breast cancer risk. These findings suggest that endogenous estrogens and exogenous estrogen-like compounds that act on the estrogen receptor and modulate E activity may partially explain racial/ethnic differences in breast cancer risk.

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Conflict of interest statement

The authors have declared that no competing interests exist.

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