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Review
. 2019 May 15:330:159-169.
doi: 10.1016/j.jneuroim.2019.03.004. Epub 2019 Mar 14.

The role of vitamin D and P2X7R in multiple sclerosis

Veronica Tsin Fong Voo  1 , Terence O'Brien  2 , Helmut Butzkueven  3 , Mastura Monif  4
Affiliations
Review

The role of vitamin D and P2X7R in multiple sclerosis

Veronica Tsin Fong Voo et al. J Neuroimmunol. .

Abstract

Multiple sclerosis (MS) is characterized by neuroinflammatory infiltrates and central nervous system demyelination. In the neuroinflammatory foci of MS there is increased expression of a purinergic receptor, P2X7R. Although implicated in the neuroinflammation, the exact role of P2X7R in the context of MS is unclear and forms the basis of this review. In this review, we also introduce the immunopathologies and inflammatory processes in MS, with a focus on P2X7R and the possible immunomodulatory role of vitamin D deficiency in this setting.

Keywords: Innate immunity; Monocytes; Multiple sclerosis; Neuroinflammation; P2X7R; Vitamin D.

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