Familial Cerebral Cavernous Malformations

Affiliations

¹ From the Departments of Neurology (A.Z., M.F., A.I., M.R., L.M.), University of New Mexico Health Sciences Center, University of New Mexico, Albuquerque.
² Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston (S.A.Q.).
³ Radiology (B.L.H., M.C.M.), University of New Mexico Health Sciences Center, University of New Mexico, Albuquerque.
⁴ Harvard University, Cambridge, MA (C.V.).
⁵ Department of Medicine and Cardiovascular Institute, University of Pennsylvania, Perelman School of Medicine, Philadelphia (A.T.T., M.L.K.).
⁶ Neurosurgery (H.Y.), University of New Mexico Health Sciences Center, University of New Mexico, Albuquerque.
⁷ Department of Neurosurgery, Barrow Neurological Institute, Phoenix, AZ (M.T.L.).
⁸ Department of Anesthesia and Perioperative Care and Department of Epidemiology and Biostatistics, University of California San Francisco (H.K.).

Review

Atif Zafar et al. Stroke. 2019 May.

. 2019 May;50(5):1294-1301.

doi: 10.1161/STROKEAHA.118.022314.

¹ From the Departments of Neurology (A.Z., M.F., A.I., M.R., L.M.), University of New Mexico Health Sciences Center, University of New Mexico, Albuquerque.
² Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston (S.A.Q.).
³ Radiology (B.L.H., M.C.M.), University of New Mexico Health Sciences Center, University of New Mexico, Albuquerque.
⁴ Harvard University, Cambridge, MA (C.V.).
⁵ Department of Medicine and Cardiovascular Institute, University of Pennsylvania, Perelman School of Medicine, Philadelphia (A.T.T., M.L.K.).
⁶ Neurosurgery (H.Y.), University of New Mexico Health Sciences Center, University of New Mexico, Albuquerque.
⁷ Department of Neurosurgery, Barrow Neurological Institute, Phoenix, AZ (M.T.L.).
⁸ Department of Anesthesia and Perioperative Care and Department of Epidemiology and Biostatistics, University of California San Francisco (H.K.).

No abstract available

Keywords: brain; developmental venous anomalies; familial cerebral cavernous malformation; hemosiderin; mutation.

Figures

1. Dalyai RT, Ghobrial G, Awad I, Tjoumakaris S, Gonzalez LF, Dumont AS, et al. Management of incidental cavernous malformations: a review. Neurosurg Focus. 2011;31:E5. doi: 10.3171/2011.9.FOCUS11211 - DOI - PubMed
1. Flemming KD, Graff-Radford J, Aakre J, Kantarci K, Lanzino G, Brown RD Jr, et al. Population-based prevalence of cerebral cavernous malformations in older adults: mayo clinic study of aging. JAMA Neurol. 2017;74:801–805. doi: 10.1001/jamaneurol.2017.0439 - DOI - PMC - PubMed
1. Petersen TA, Morrison LA, Schrader RM, Hart BL. Familial versus sporadic cavernous malformations: differences in developmental venous anomaly association and lesion phenotype. AJNR Am J Neuroradiol. 2010;31:377–382. doi: 10.3174/ajnr.A1822 - DOI - PMC - PubMed
1. Morrison L, Akers A. Cerebral cavernous malformation, familial In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, et al., eds. Genereviews® [Internet]. Seattle, WA: University of Washington, Seattle; 1993–2019.
1. Haasdijk RA, Cheng C, Maat-Kievit AJ, Duckers HJ. Cerebral cavernous malformations: from molecular pathogenesis to genetic counselling and clinical management. Eur J Hum Genet. 2012;20:134–140. doi: 10.1038/ejhg.2011.155 - DOI - PMC - PubMed