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Review
. 2019 May;50(5):1294-1301.
doi: 10.1161/STROKEAHA.118.022314.

Familial Cerebral Cavernous Malformations

Atif Zafar  1 , Syed A Quadri  2 , Mudassir Farooqui  1 , Asad Ikram  1 , Myranda Robinson  1 , Blaine L Hart  3 , Marc C Mabray  3 , Catherine Vigil  4 , Alan T Tang  5 , Mark L Kahn  5 , Howard Yonas  6 , Michael T Lawton  7 , Helen Kim  8 , Leslie Morrison  1
Affiliations
Review

Familial Cerebral Cavernous Malformations

Atif Zafar et al. Stroke. 2019 May.
No abstract available

Keywords: brain; developmental venous anomalies; familial cerebral cavernous malformation; hemosiderin; mutation.

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Figures

Figure 1.
Figure 1.
Flow chart showing the management for the symptomatic and asymptomatic cerebral cavernous malformation (CCM) patients. AED indicates antiepileptic drug; and MRI, magnetic resonance imaging.
Figure 2.
Figure 2.
A solitary cerebral cavernous malformation (CCM) with characteristic hypointense ring on (A) T2, (B) T2 *GRE, and (C) SWI. GRE indicates gradient recalled echo; and SWI, susceptibility-weighted imaging.
Figure 3.
Figure 3.
SWI is far more superior to T2*-weighted GRE MRI (B) and conventional T2 sequences (C) to detect smaller type-IV cerebral cavernous malformations (CCMs). Punctate hypointense lesions, black dots with blooming can be noticed both on SWI (A) and T2*-weighted GRE (B). The figure clearly demonstrates SWI to be more sensitive in identifying even small lesions in the same FCCM patient compared with T2*-weighted GRE which can identify most of the cavernomas except micro lesions. FCCM indicates familial cerebral cavernous malformation; GRE, gradient recalled echo; MRI, magnetic resonance imaging; and SWI, susceptibility-weighted imaging.
See this image and copyright information in PMC

References

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