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. 2019 Mar 25;20(1):183.
doi: 10.1186/s13063-019-3270-2.

The REstart or STop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: statistical analysis plan for a randomised controlled trial

Rustam Al-Shahi Salman  1   2 , Gordon D Murray  3 , Martin S Dennis  4 , David E Newby  5 , Peter A G Sandercock  4 , Nikola Sprigg  6 , Cathie L M Sudlow  4   3 , David J Werring  7 , Philip M White  8 , William N Whiteley  4
Affiliations

The REstart or STop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: statistical analysis plan for a randomised controlled trial

Rustam Al-Shahi Salman et al. Trials. .

Abstract

Background: For adults surviving stroke due to spontaneous (non-traumatic) intracerebral haemorrhage (ICH) who had taken an antithrombotic (i.e. anticoagulant or antiplatelet) drug for the prevention of vaso-occlusive disease before the ICH, it is unclear whether starting antiplatelet therapy modifies the risks of recurrent ICH, major haemorrhagic events, major occlusive vascular events, or a composite of all major vascular events compared to avoiding antiplatelet therapy.

Methods/design: The REstart or STop Antithrombotics Randomised Trial (RESTART) is an investigator-led, parallel group, open, assessor-blind, randomised trial comparing starting versus avoiding antiplatelet therapy for adults surviving antithrombotic-associated ICH. Recruitment began on 22 May 2013 and ended on 31 May 2018. Follow-up ended on 30 November 2018. This update to the protocol describes the statistical analysis plan (version 1.7, finalised on 25 January 2019). Database lock and un-blinding occurred on 29 January 2019, after which the un-masked trial statistician conducted the final analyses according to this statistical analysis plan.

Discussion: Final results of RESTART will be analysed and disseminated in May 2019.

Trial registration: ISRCTN registry 71907627 . Prospectively registered on 25 April 2013.

Keywords: Secondary prevention; antiplatelet therapy; intracerebral haemorrhage; randomised controlled trial; statistical analysis plan; stroke.

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Conflict of interest statement

Ethics approval and consent to participate

The Scotland A research ethics committee approved RESTART before recruitment began (reference 12/SS/0138).

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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