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Review
. 2019 Mar 20;22(3):167-172.
doi: 10.3779/j.issn.1009-3419.2019.03.09.

[Application of Metabolic Parameters Measured by ¹⁸F-FDG PET/CT in the Evaluation of the Prognosis of Non-small Cell Lung Cancer]

[Article in Chinese]
Tao Wang  1 , Zhenguang Wang  1
Affiliations
Review

[Application of Metabolic Parameters Measured by ¹⁸F-FDG PET/CT in the Evaluation of the Prognosis of Non-small Cell Lung Cancer]

[Article in Chinese]
Tao Wang et al. Zhongguo Fei Ai Za Zhi. .

Abstract
in English, Chinese

Tumor-node-metastasis (TNM) staging system is the most important basis for making therapeutic decisions and predicting prognosis of lung cancer patients. The metabolic parameters including standardized uptake value (SUV), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) measured by ¹⁸F-fluorodeoxyglucose-positron emission tomography (¹⁸F-FDG PET/CT) associate with tumor aggressiveness and can provide additional prognostic information. A new staging methodology combines the conventional cTNM with the metabolic tumor burden quantified from the PET images is a better predictor of overall survival with superior stratifying power may help oncologists to make better treatment plans. ¹⁸F-FDG PET/CT image texture analysis, as an emerging research tool, is used to quantify the spatial heterogeneity of radioactive uptake in tumors, thereby to explore the biological characteristics of the tumor. This article reviews developments in evaluating the ¹⁸F-FDG PET/CT metabolic parameters and its role as a prognostic factor for non-small cell lung cancer. .

【中文题目：¹⁸F-FDG PET/CT代谢参数在非小细胞肺癌预后评估中的应用及进展】 【中文摘要：基于肺癌肿瘤-淋巴结-转移（tumor-node-metastasis, TNM）分期的治疗方案制定和预后评价是目前国内外肺癌指南中的基本原则。18氟代脱氧葡萄糖正电子发射计算机断层显像（¹⁸F-deoxyglucose positron emission tomography/computed tomography, ¹⁸F-FDG PET/CT）代谢参数如标准摄取值（standardized uptake value, SUV）、肿瘤代谢体积（metabolic tumor volume, MTV）、病灶糖酵解总量（total lesion glycolysis, TLG）可以反映肿瘤侵袭性的信息，提供额外的预后信息。将量化的肿瘤代谢负荷MTV、TLG联合传统的TNM分期对患者进行危险分层，作为一种新的分期方式可以辅助临床医师制定更为合适的治疗方案。¹⁸F-FDG PET/CT图像纹理分析作为一种新兴研究方法，可以量化肿瘤内放射性摄取的空间分布异质性，进而了解肿瘤的生物学特征。本文对¹⁸F-FDG PET/CT代谢参数在非小细胞肺癌患者预后评估的应用进行阐述。 】 【中文关键词：肺肿瘤；肿瘤代谢参数；预后评估】.

Keywords: Lung neoplasms; Metabolic parameters; Prognostic evaluation.

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