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Review
. 2016 Dec 1;1(4):183-191.
doi: 10.1515/pp-2016-0022. Epub 2016 Dec 20.

Pharmacokinetic problems in peritoneal drug administration: an update after 20 years

Michael F Flessner  1
Affiliations
Review

Pharmacokinetic problems in peritoneal drug administration: an update after 20 years

Michael F Flessner. Pleura Peritoneum. .

Abstract

Intraperitoneal chemotherapy has demonstrated significant pharmacologic and clinical advantage over traditional intravenous administration for cancers that are restricted to the peritoneal cavity. The combination of cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) has become the standard technique used to fight ovarian and gastrointestinal cancers in many centers. However, challenges remain for HIPEC to contact the entire peritoneal surface, penetrate the tumor tissue, and transport to the lymphatics and other metastatic sites. New innovations in delivery technique, such as heated aerosol, and in delivery molecules, such as microparticles, nanoparticles, nanogels, and tumor-penetrating peptides are being tested in animal models and will likely soon be in human trials. Improvements in overall care, such as the recent clinical trial of an oral agent for maintenance therapy in ovarian carcinoma, will continue in this field for the next 20 years.

Keywords: contact area; cytoreductive surgery; drug penetration; hyperthermic intraperitoneal chemotherapy; tumor-penetrating nanoparticles.

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