Can Aliskiren "COMPLEMENT" our management of kidney disease?
- PMID: 30912232
- PMCID: PMC8030379
- DOI: 10.1111/jch.13524
Can Aliskiren "COMPLEMENT" our management of kidney disease?
Keywords: Aliskiren; complement; glomerular; renin.
Conflict of interest statement
None.
Comment on
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Aliskiren inhibits renin-mediated complement activation.Kidney Int. 2018 Oct;94(4):689-700. doi: 10.1016/j.kint.2018.04.004. Epub 2018 Jun 5. Kidney Int. 2018. PMID: 29884545
References
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- Kelly DJ, Zhang Y, Moe G, Naik G, Gilbert RE. Aliskiren, a novel renin inhibitor, is renoprotective in a model of advanced diabetic nephropathy in rats. Diabetologia. 2007;50(11):2398‐2404. - PubMed
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- Ichihara A, Sakoda M, Kurauchi‐Mito A, et al. New approaches to blockade of the renin‐angiotensin‐aldosterone system: characteristics and usefulness of the direct renin inhibitor Aliskiren. J Pharmacol Sci. 2010;113(4):296‐300. - PubMed
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- Persson F, Rossing P, Schjoedt KJ, et al. Time course of the antiproteinuric and antihypertensive effects of direct renin inhibition in type 2 diabetes. Kidney Int. 2008;73(12):1419‐1425. - PubMed
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