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Comment
. 2019 Mar 25;48(6):741-742.
doi: 10.1016/j.devcel.2019.03.007.

Prometheus Unbound in Ya(p) Heart

Jan W Buikema  1 , Sean M Wu  2
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Prometheus Unbound in Ya(p) Heart

Jan W Buikema et al. Dev Cell. .
Free article

Abstract

The adult mammalian heart, unlike in some amphibian and fish species, is generally considered a post-mitotic organ. In this issue of Developmental Cell, Monroe et al. (2019) show that the expression of constitutively active YAP induces a remarkable degree of proliferation in preexisting adult cardiomyocytes by globally altering chromatin accessibility.

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