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. 2018 Sep;25(5):79-87.
doi: 10.21315/mjms2018.25.5.8. Epub 2018 Oct 30.

Preliminary Comparative Study of Oral7® Versus Salt-Soda Mouthwash on Oral Health Related Problems and Quality of Life among Head and Neck Cancer Patients Undergoing Radiotherapy

Norsa'adah Bachok  1 , Biswa Mohan Biswal  2 , Noor Hayati Abdul Razak  3 , Wan Mohd Nazri Wan Zainoon  4 , Kasmawati Mokhtar  3 , Roselinda Abdul Rahman  3 , Mohd Faizal Abdullah  3 , Siti Mimi Nadiya Mustafa  4 , Nawi Noza  4
Affiliations

Preliminary Comparative Study of Oral7® Versus Salt-Soda Mouthwash on Oral Health Related Problems and Quality of Life among Head and Neck Cancer Patients Undergoing Radiotherapy

Norsa'adah Bachok et al. Malays J Med Sci. 2018 Sep.

Abstract

Background: This quasi-clinical trial compared the effects of Oral7® and salt-soda mouthwash on the development of dental caries, salivary gland function, radiation mucositis, xerostomia and EORTC QLQ H&N C35 scores in head and neck cancer patients who underwent radiotherapy.

Methods: We included patients with histopathologically diagnosed head and neck cancers who had received radiation, with an Eastern Cooperative Oncology Group (ECOG) performance status 0-1 and age range of 15-60 years. Patients with prior radiotherapy and chemotherapy, edentulous status, total parotidectomy, sicca syndrome or on xerosis-induced medications were excluded. We assigned 15 patients each to the Oral7® and salt-soda groups.

Results: There was no significant difference in the mean Decayed, Missing and Filling Teeth (DMFT) score between groups. Head and neck cancer patients who were on Oral7® had a significantly better quality of life than those on salt-soda in relation to the swallowing problems, social eating, mouth opening, xerostomia and illness scales. Patients who were on Oral7® had a significantly lower xerostomia score than patients on salt-soda mouthwash. Patients on Oral7® had a significantly lower mucositis score in week 5-7 compared to patients in the salt-soda group.

Conclusion: Oral7® showed advantages over salt-soda solution in relation to reducing xerostomia, easing radiation-induced mucositis, and improving quality of life, despite the non-significant difference in the dental caries assessment.

Keywords: artificial saliva; mouthwashes; radiation effects; xerostomia.

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Conflict of interest statement

Conflicts of Interest None

Figures

Figure 1
Figure 1
Comparison of xerostomia score between Oral7® and salt-soda mouthwash groups among head and neck cancer patients who underwent radiotherapy
Figure 2
Figure 2
Comparison of radiation mucositis score between Oral7® and salt-soda mouthwash groups among head and neck cancer patients who underwent radiotherapy
See this image and copyright information in PMC

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