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. 2018 Sep;25(5):103-114.
doi: 10.21315/mjms2018.25.5.10. Epub 2018 Oct 30.

Evaluation of Adverse Reactions Induced by Anti-Tuberculosis Drugs in Hospital Pulau Pinang

Cheah Meng Fei  1 , Hadzliana Zainal  2 , Irfhan Ali Hyder Ali  3
Affiliations

Evaluation of Adverse Reactions Induced by Anti-Tuberculosis Drugs in Hospital Pulau Pinang

Cheah Meng Fei et al. Malays J Med Sci. 2018 Sep.

Abstract

Background: The use of multi-drug regimens in tuberculosis (TB) treatment has been associated with undesirable adverse drug reactions (ADRs). This study aims to assess the incidence and impact of ADRs on TB treatment in Hospital Pulau Pinang.

Methods: This cross-sectional study was conducted via retrospective review of outpatients' medical records. Details regarding ADRs were identified by a pharmacist and verified by a consultant respiratory physician.

Results: A total of 91 cases, out of 210 patients enrolled in this study, were detected with 75 patients (35.7%) experienced at least one ADR. The three most common ADRs detected were cutaneous adverse drug reactions (CADRs) (21.0%), drug-induced hepatitis (DIH) (7.1%) and gastrointestinal disturbance (4.8%). Pyrazinamide was the most common causative agent and 15.7% of all TB patients required treatment modification due to ADRs. Females were shown to have a higher tendency to develop ADRs than the males in this study (P = 0.009). The development of ADRs was shown not to affect the TB treatment outcomes (P = 0.955).

Conclusion: The incidence of ADRs in this study was high so it is important to identify the risk factors for ADRs and the individuals who have those risk factors when initiating anti-TB drugs. These individuals require special attention when anti-TB drugs are initiated.

Keywords: adverse drug reactions; anti-tuberculosis drugs; incidence; relationship; treatment outcomes.

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Conflict of interest statement

Conflicts of Interest None

References

    1. World Health Organisation. Global tuberculosis report 2016. Geneva, Switzerland: World Health Organization; 2016.
    1. Ministry of Health Malaysia. Clinical practice guidelines: management of tuberculosis. 3rd ed. Putrajaya, Malaysia: 2012.
    1. World Health Organisation. Treatment of tuberculosis guidelines. 4th ed. Geneva, Switzerland: World Health Organization; 2010.
    1. American Society of Health-System Pharmacists. ASHP guidelines on adverse drug reaction monitoring and reporting. Am J Health Syst Pharm. 1995;52:417–419. - PubMed
    1. Koh Y, Yap CW, Li SC. A quantitative approach of using genetic algorithm in designing a probability scoring system of an adverse drug reaction assessment system. International Journal of Medical Informatics. 2008;77(6):421–430. doi: 10.1016/j.ijmedinf.2007.08.010. - DOI - PubMed

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