Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 May 1;10(3):546-548.
doi: 10.1093/advances/nmy086.

Calcium

Affiliations

Calcium

Connie M Weaver et al. Adv Nutr. .

Abstract

Calcium is the fifth most abundant element in the body with >99% residing in the skeleton as hydroxyapatite, a complex calcium phosphate molecule. This mineral supplies the strength to bones that support locomotion, but it also serves as a reservoir to maintain serum calcium concentrations. Calcium plays a central role in a wide range of essential functions. Its metabolism is regulated by 3 major transport systems: intestinal absorption, renal reabsorption, and bone turnover. Calcium transport in these tissues is regulated by a sophisticated homeostatic hormonal system that involves parathyroid hormone, and 1,25-dihydroxyvitamin D in response to decreased serum ionized calcium, detected by the calcium-sensing receptor (1).

PubMed Disclaimer

References

    1. Peacock M. Calcium metabolism in health and disease. Clin J Am Soc Nephrol. 2010;5:s23–30. - PubMed
    1. Zhao JG, Zeng XT, Wang J, Liu L. Association between calcium or vitamin D supplementation and fracutre incidence in community-dwelling older adults: a systematic review and meta-analysis. JAMA. 2017; 328:2466–82. - PMC - PubMed
    1. Weaver CM, Heaney RP. Calcium. In: Shils ME, Shike M, Ross AC, Caballero B, Cousins RJ, editors. Modern nutrition in health and disease. 10th ed Baltimore (MD): Lippincott Williams & Wilkins; 2006. p. 194–210.
    1. Institute of Medicine. Dietary reference intakes for calcium and vitamin D. Washington (DC): The National Academies Press; 2011. - PubMed
    1. Blumberg JB, Frei BB, Fulgoni VL, Weaver CM, Zeisel SH. Impact of frequency of multi-vitamin/multi-mineral supplement intake on nutritional adequacy and nutrient deficiencies in U.S. adults. Nutrients. 2017;9:849–67. - PMC - PubMed