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. 2019 May;38(4):435-442.
doi: 10.1111/dar.12922. Epub 2019 Mar 27.

Prevalence of cognitive impairment in patients with substance use disorder

Carolien J W H Bruijnen  1   2   3 , Boukje A G Dijkstra  2   4 , Serge J W Walvoort  1   2 , Wiebren Markus  2   5 , Joanne E L VanDerNagel  2   6   7 , Roy P C Kessels  1   3   8 , Cornelis A J DE Jong  2   9
Affiliations

Prevalence of cognitive impairment in patients with substance use disorder

Carolien J W H Bruijnen et al. Drug Alcohol Rev. 2019 May.

Abstract

Introduction and aims: Cognitive impairments in substance use disorder predict treatment outcome and are assumed to differ between substances. They often go undetected, thus the current study focuses on the prevalence of and differences in cognitive functioning across substances by means of a cognitive screen at the early stage of addiction treatment.

Design and methods: The Montreal Cognitive Assessment was administered to outpatients seeking treatment for substance use disorder. Patient characteristics (age, years of regular use, polysubstance use, severity of dependence/abuse, depression, anxiety and stress) were also taken into account.

Results: A total of 656 patients were included (n = 391 used alcohol, n = 123 used cannabis, n = 100 used stimulants and n = 26 used opioids). The prevalence of cognitive impairments was 31%. Patients using alcohol had a lower total- and memory domain score than those using cannabis. Patients using opioids scored lower on visuospatial abilities than those using cannabis or stimulants. Younger patients scored higher than older patients. No effect was found for the other investigated characteristics.

Discussion and conclusions: Given the high prevalence of cognitive impairments, standard screening at an early stage of treatment is important to determine the course of treatment and maximise treatment outcome. Caution is needed in interpreting results about opioids due to an underrepresentation of this patient group, and more research is needed on the effect of age on Montreal Cognitive Assessment performance.

Keywords: Montreal cognitive assessment; cognitive impairment; prevalence; substance use disorder.

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Conflict of interest statement

The authors have no conflicts of interest.

References

    1. American Psychiatric Association . Diagnostic and statistical manual of mental disorders, 5th edn. Washington: American Psychiatric Publishing, 2013.
    1. Toledo‐Fernández A, Brzezinski‐Rittner A, Roncero C, Benjet C, Salvador‐Cruz J, Marín‐Navarrete R. Assessment of neurocognitive disorder in studies of cognitive impairment due to substance use disorder: a systematic review. J Subst Use 2018;23:535–50.
    1. Copersino ML, Fals‐Stewart W, Fitzmaurice G, Schretlen DJ, Sokoloff J, Weiss RD. Rapid cognitive screening of patients with substance use disorders. Exp Clin Psychopharmacol 2009;17:337–44. - PMC - PubMed
    1. Lyvers M, Tobias‐Webb J. Effects of acute alcohol consumption on executive cognitive functioning in naturalistic settings. Addict Behav 2010;35:1021–8. - PubMed
    1. Peterson JB, Rothfleisch J, Zelazo PD, Pihl RO. Acute alcohol intoxication and cognitive functioning. J Stud Alcohol 1990;51:114–22. - PubMed

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