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Clinical Trial
. 1986 Aug;15(4):389-94.
doi: 10.1016/s0300-9785(86)80026-6.

A double-blind, randomized study of naproxen and acetylsalicylic acid after surgical removal of impacted lower third molars

S Sindet-Pedersen, J K Petersen, P C Gøtzsche, H Christensen
Clinical Trial

A double-blind, randomized study of naproxen and acetylsalicylic acid after surgical removal of impacted lower third molars

S Sindet-Pedersen et al. Int J Oral Maxillofac Surg. 1986 Aug.

Abstract

100 patients had an impacted lower 3rd molar surgically removed in a double-blind study. Naproxen (500 mg b.i.d.) or acetylsalicylic acid (ASA) (1 g t.i.d.) were administered to the patients. Paracetamol was allowed as escape medication. 49 patients received naproxen and 51 ASA. 4 patients from each group were excluded because they took other analgesics, took too few tablets, were lost to follow-up or had misunderstood the instructions. There was a significantly better over all analgesic effect of naproxen than ASA (p = 0.004). More patients in the naproxen group than in the ASA group (p less than 0.01) would accept treatment with the same drug again. 4 patients, all from the ASA group, complained spontaneously about side effects.

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